However, the primary adverse effect limiting their use is myopathy. This study examines the efficacy and safety of red yeast rice RYR , a source of natural statins, as compared with atorvastatin, which is the most widely used synthetic statin.
Statin interference with the endogenous synthesis of coenzyme Q10 CoQ10 prompted the hypothesis that its deficiency may be implicated in the pathogenesis of statin-associated myopathy. Some dosage guidelines have been suggested, but talk to your doctor about your appropriate dose. A study published in the issue of ''Biofactors'' tested the effects of CoQ10 supplementation on subjects who had discontinued their statin drugs due to side effects.
On average, subjects took mg and they reported significant reductions in adverse reactions associated with statins, such as muscle pain and fatigue. The study noted an ''average'' dose of mg, meaning the actual dose varied between participants. The University of Maryland Medical Center suggests a dose of to mg at night to prevent red-yeast-rice-related CoQ10 deficiency.
Ultimately, your doctor can determine the most appropriate dose based on your individual circumstances. If you have already begun experiencing side effects related to low levels, you might require a different dose than someone who just started the supplement for prevention.
Tell each of your healthcare providers about all your medical conditions, allergies, and all medicines you use. Red yeast rice is a product that is made by fermenting red rice with a certain type of yeast. Red yeast rice is also known as Cholestin, Hypocol, Xuezhikang, or Zhitai.
Red yeast rice supplements are not the same as red yeast rice that is sold in Chinese grocery stores. Red yeast rice has been used in alternative medicine as a likely effective aid in reducing levels of "bad" cholesterol low-density lipoprotein, or LDL and triglycerides in the blood. Red yeast rice has been used as a possibly effective aid in reducing the risk of heart disease, heart attacks, or death in people with a history of heart attack.
Red yeast rice has also been used as a possibly effective aid in lowering cholesterol and triglyceride levels in people with human immunodeficiency virus HIV. Red yeast rice has been used to treat high blood pressure. However, research has shown that red yeast rice may not be effective in treating this condition.
Other uses not proven with research have included: lowering cholesterol and blood sugar levels in people with diabetes, improving blood circulation, lowering liver enzymes associated with liver damage, and treating diarrhea, indigestion, or other stomach problems.
It is not certain whether red yeast rice is effective in treating any medical condition. Medicinal use of this product has not been approved by the FDA. Red yeast rice should not be used in place of medication prescribed for you by your doctor. Red yeast rice is often sold as an herbal supplement. There are no regulated manufacturing standards in place for many herbal compounds and some marketed supplements have been found to be contaminated with toxic metals or other drugs.
Talk with your healthcare provider before using red yeast rice to lower your cholesterol. You should not use red yeast rice in place of any medication that has been prescribed by your doctor. Ask a doctor, pharmacist, or other healthcare provider if it is safe for you to use this product if you have ever had:. Red yeast rice has caused birth defects in animals and is considered likely unsafe to use during pregnancy.
Do not use this product without medical advice if you are pregnant. It is not known whether red yeast rice passes into breast milk or if it could harm a nursing baby. American Heart Association. Red yeast rice for dysipidemia. Mo Med. Multicenter clinical trial of serum lipid-lowering effects of a Monascus purpureus red yeast rice preparation from traditional Chinese medicine.
Curr Ther Res. Lipid-lowering efficacy of red yeast rice in a population intolerant to statins. The Am J Cardiol. Chinese red rice depletes muscle coenzyme Q10 and maintains muscle damage after discontinuation of statin treatment. J Am Geriatr Soc.
Treatment Several studies suggest that red yeast rice reduces high cholesterol. These studies support the claim that red yeast rice lowers cholesterol: One study by UCLA School of Medicine involved 83 people with high cholesterol levels.
Those who took red yeast rice over a 12 week period had lower levels of total cholesterol, LDL cholesterol, and triglycerides fats in the blood compared to those taking placebo. HDL "good" cholesterol levels did not change in either study group. In the study, people had mild-to-moderately high levels of total cholesterol and LDL cholesterol. In another 8-week study of people with high cholesterol, those who took red yeast rice had a drop in cholesterol levels compared to those who took placebo.
Total cholesterol fell by Dietary Sources Asia, and Chinese communities in North America, use red yeast rice in powdered form as a food coloring for fish, alcoholic beverages, and cheese. Dosage and Administration Red yeast rice is an ingredient in several supplements advertised to promote heart health. Pediatric People younger than 20 should not use red yeast rice supplements. Precautions Researchers do not know whether it is safe to use red yeast rice for longer than 12 weeks.
Side Effects Side effects of red yeast rice are rare but can include: Headache Stomachache or bloating Gas Dizziness Heartburn Muscle aches and weakness. This can lead to a rare but serious condition called rhabdomyolysis.
Stop taking red yeast rice immediately and call your doctor Pregnancy and Breastfeeding Pregnant and breastfeeding women should not take red yeast rice. Pediatric Use People under 20 should not take red yeast rice until more research is done. Geriatric Use No studies have looked at the safety of red yeast rice in older adults.
Interactions and Depletions Cholesterol-lowering medications: If you take drugs to lower your cholesterol, you should not take red yeast rice unless your doctor tells you to. Mark D. All red yeast rice products are not created equal.
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